Jun Wan

This study identifies PARP1 catalytic domain mutations as a mechanism of high-level resistance to saruparib in BRCA1-deficient breast cancer cells, while retaining DDR vulnerabilities.

This study identifies CDH3 as a key driver of basal-like prostate cancer and shows that CDH3-targeted therapies like ADCs and CAR T cells are effective in preclinical models.

DiCE identifies disease-associated genes by combining differential expression with network centrality analysis, validated on prostate cancer datasets to find genes correlated with disease-free survival.

This study identifies RABEP1 as a key regulator of neutrophil migration by promoting endosomal recycling, Rac activation, and actin polymerization in zebrafish and human cells.

This study identifies two distinct waves of CD8+ CAR T-cell differentiation in DLBCL patients, showing they originate from different precursor populations with distinct phenotypes and ontogenies.

This study shows that inhibiting RPA gap protection enhances PARP inhibitor efficacy in BRCA1-deficient cancers by increasing genomic instability and reducing tumor growth.

This study identifies ZNFX1 as a master regulator of epigenetically-induced pathogen mimicry and inflammasome signaling in ovarian cancer, linking its expression to disease progression and survival.

The paper identifies a novel marker gene set, CDHu40, for neuroendocrine prostate cancer (NEPC) using gene expression and PPI network analysis, showing strong prognostic significance.

This study uses single-cell transcriptomics to analyze FGF23 bioactivity and identify novel inflammatory targets in the kidney, revealing interactions between FGF23 and TNF/NF-κB pathways.

The paper investigates how the duration of the terminal phase of human life affects postmortem gene expression in skin, finding prolonged terminal phases induce survival pathways and downregulate organ-specific functions.

This study shows SARS-CoV-2 genes Nsp6, Nsp8, and M reduce ATP levels in hPSC-CMs, causing apoptosis and dysfunction, and identifies drugs that may counteract these effects.

The paper identifies AREG as a critical driver of bleomycin-induced skin fibrosis and shows that targeting the AREG-EGFR-MEK pathway can prevent fibrosis.

The paper withdraws its manuscript due to the need for further experimental validation of its conclusions.

This study shows Foxd1 is required for sustained expression of genes in mature anterior hypothalamic neurons, but not for initial patterning.

This study investigates EMT in stem cell-derived RPE cells, identifying dysregulated axon guidance molecules during the process.

This study identifies Lhx2 as a key regulator of chromatin accessibility and transcription factor binding in retinal progenitor cells, showing its role in stage-specific gene regulation.