Jun Huang

This study shows that low-strength type I interferon signaling enhances CAR T-cell efficacy against B-cell lymphoma and leukemia without causing in vivo toxicity.

This study develops a polymer-lipid hybrid nanoparticle (PLNP) to enhance mRNA delivery and T cell immunity, showing improved antigen-specific T cell responses and protection against viral variants and cancer.

DiCE identifies disease-associated genes by combining differential expression with network centrality analysis, validated on prostate cancer datasets to find genes correlated with disease-free survival.

This study identifies two distinct waves of CD8+ CAR T-cell differentiation in DLBCL patients, showing they originate from different precursor populations with distinct phenotypes and ontogenies.

This study compares immune responses and metabolism in SARS-CoV-2 and HIV-1 infections using single-cell transcriptomics, identifying shared and distinct features in 94,442 PBMCs from 16 patients.

This study shows that TCR-pMHC bond length controls TCR ligand discrimination by affecting CD3ζ ITAM phosphorylation and downstream signaling.