Extracellular matrix context shapes morphogenesis and lactation-associated states in human milk-derived mammary organoids
Amelia Hasenauer, Valerie G. Pascetta, Maxwell C. McCabe, Anthony J. Saviola, Simone Ponta, Mehmet Yilmaz, Verena Boßung, Christina Louisa Coelius, Thomas Biesgen, Kirk Charles Hansen, Stefan Preković, Nicole Ochsenbein‐Kölble, Marcy Zenobi‐Wong
This study shows that human milk-derived mammary epithelial cells form organoids that respond differently to various extracellular matrix environments, revealing ECM's role in shaping morphogenesis and lactation states.
bioRxiv · Aug 24, 2026 · PreprintCell Biology