Anthony J. Saviola

This study shows that human milk-derived mammary epithelial cells form organoids that respond differently to various extracellular matrix environments, revealing ECM's role in shaping morphogenesis and lactation states.

This study identifies NAMPT as a metabolic vulnerability in HR-MDS HSPCs, showing its inhibition reduces their survival and disease burden.

This paper characterizes the RBC proteome across 13,091 donors, identifies genetic regulators of molecular aging, and shows that aging clocks predict hemolysis, transfusion outcomes, and donor activity.

This study identifies ERG as a vulnerability in IKZF1-mutated B-cell acute lymphoblastic leukemia through gene regulatory network analysis and functional validation.

The paper defines the Band 3 N-terminus interactome in red blood cells, revealing its role in hypoxic adaptation through BLVRB-dependent S-nitroso transfer and metabolic remodeling.

This study shows that TGFβ from cardiomyocytes programs fibroblast development and ECM environment to support cardiomyocyte maturation in the developing heart.

This study shows that IL15/IL15Rα complex with radiation therapy requires Treg depletion to induce anti-tumor immunity and that PD1-IL2v enhances CD8 T cell activation and function.

The paper develops a method to identify N-terminal cross-linked peptides from collagen I in Achilles tendon using mass spectrometry, revealing differences in cross-links in bovine pulmonary hypertension.

This study compares ECM proteomic changes during ear punch regeneration in Acomys cahirinus and Mus musculus, identifying differences in ECM proteins, crosslinking enzymes, and CD206 expression.

The paper characterizes two distinct serine protease groups in puff adder venom, revealing novel gelatinase activity and structural insights into their substrate specificity and functional roles.

This paper develops a 3D biomimetic scaffold model to support in vitro lactation by human milk-derived mammary epithelial cells, enabling secretion of beta-casein and milk-fat-globules.

This study uses untargeted peptidomics and thrombolysis assays to analyze the clot-degrading effects of six snake venoms, revealing specific targets and mechanisms of thrombolysis.

This study shows that combining immunotherapies can lead to divergent tumor responses based on the tumor microenvironment, with Treg depletion reversing progression in pancreatic cancer.

This study shows that targeting the EphB4-ephrinB2 axis with engineered ligands reduces metastasis in HNSCC by modulating tumor microenvironment and immune responses.

The paper analyzes nanobubble ultrasound contrast agent kinetics and angiogenic signaling in head and neck cancer using pixel clustering and proteomics.

This study investigates the dual role of EphA4 in T regulatory cells and tumor-associated macrophages during HNSCC progression, showing pro-tumoral and anti-tumoral effects respectively.

The paper identifies PP1 phosphatase activity in the PPWZ complex as essential for antisense transcription termination by dephosphorylating RNA pol II CTD Ser5.

This study characterizes the diversity and bioactivity of venom metalloproteases in puff adders, identifying distinct forms with varying enzymatic activities and proposing a new nomenclature for the dominant SVMPs.

The paper humanizes yeast U1 snRNP components to study 5 ss recognition, finding that U1C ZnF substitution causes splicing defects and mitochondrial dysfunction.

This study investigates age- and sex-related metabolic changes in female brains and microglia, finding that estrogen may suppress disease-associated microglia (DAM) factors, potentially increasing Alzheimer's disease risk in post-menopausal women.

This paper creates a mass spectrometry-based atlas of ECM proteins across 25 mouse organs, revealing shared and tissue-specific ECM protein profiles.