Maxwell C. McCabe

This study investigates the effects of different molecular weight components of an intravascularly infusible decellularized extracellular matrix (iECM) on vascular binding and pro-reparative gene expression after myocardial infarction.

This study develops sex- and disease-informed biomaterial design criteria from human lung tissue to create engineered hybrid-hydrogels that recapitulate mechanical and biochemical features of IPF.

This study shows that human milk-derived mammary epithelial cells form organoids that respond differently to various extracellular matrix environments, revealing ECM's role in shaping morphogenesis and lactation states.

The paper shows that collagen abundance alone does not define fibrosis in DMD, as distinct matrix states with different biological activities and mechanosignaling exist.

This study develops human-derived granular extracellular matrix hydrogels for osteochondral repair, showing distinct biochemical and mechanical properties between cartilage and bone gECM.

This study identifies NAMPT as a metabolic vulnerability in HR-MDS HSPCs, showing its inhibition reduces their survival and disease burden.

This study shows particle-only gECM wafers match hydrogel wafers in mechanical and biological performance without needing secondary polymers.

This study identifies sex-biased protein expression in healthy and fibrotic human lung regions, highlighting potential biological mechanisms for sex differences in idiopathic pulmonary fibrosis.

This study develops and characterizes granular ECM hydrogels for five tissues, showing they retain shape, stability, and support tissue-specific cellular activity.

A granular extracellular matrix hydrogel implanted in a goat condyle provided a robust repair, filling the defect tissue with integrated, hyaline-like cartilage at 12 months.

This study identifies Awp11, an adhesin-like effector in Candida glabrata, as a key determinant of strain-dependent immunogenicity and gut colonization.

This study shows that deleting Yap/Taz in mouse dermal fibroblasts impairs collagen production and deposition, affecting postnatal skin development.

The paper develops a method to identify N-terminal cross-linked peptides from collagen I in Achilles tendon using mass spectrometry, revealing differences in cross-links in bovine pulmonary hypertension.

This study compares ECM proteomic changes during ear punch regeneration in Acomys cahirinus and Mus musculus, identifying differences in ECM proteins, crosslinking enzymes, and CD206 expression.

This paper develops a 3D biomimetic scaffold model to support in vitro lactation by human milk-derived mammary epithelial cells, enabling secretion of beta-casein and milk-fat-globules.

This study uses untargeted peptidomics and thrombolysis assays to analyze the clot-degrading effects of six snake venoms, revealing specific targets and mechanisms of thrombolysis.

This study develops a light-based bioprinting method using decellularized extracellular matrix to create anisotropic cartilage scaffolds that promote tissue maturation and mimic native structure.

This paper creates a mass spectrometry-based atlas of ECM proteins across 25 mouse organs, revealing shared and tissue-specific ECM protein profiles.