Molecular prosthetics and CFTR modulators additively increase secretory HCO- flux in cystic fibrosis airway epithelia
Nohemy Celis, Danforth P. Miller, Thomas E. Tarara, Jeffry G. Weers, Ian M. Thornell, Michael J. Welsh, Martin D. Burke
This study shows that combining CFTR modulators with amphotericin B increases HCO3- secretion and airway surface liquid pH in CF airway epithelia more than either treatment alone.
ACS Chemical Biology · Oct 20, 2025Peer-reviewedPharmacology & Toxicology