Stimulation of the Medial SNr Promotes Sustained Motor Recovery and Counteracts Parkinsonian Pathophysiology in Dopamine Depleted Mice
Asier Aristieta, John E. Parker, Mary D. Cundiff, Thomas Fuchs, Byung Kook Lim, Jonathan E. Rubin, Aryn H. Gittis
This study shows that stimulating specific neurons in the SNr of dopamine-depleted mice leads to sustained motor recovery and reduced parkinsonian symptoms, while global SNr inhibition only provides temporary effects.
bioRxiv · Dec 9, 2024 · PreprintNeuroscience