Asier Aristieta

L-DOPA Rescues Reach Height but Not Trajectory Area in a Bimanual String-Pulling Behavior in Parkinsonian Rats

This study shows that L-DOPA improves certain motor features but not others in a bimanual string-pulling task in Parkinsonian rats.

Altered SNr activity under dopamine depletion: mechanistic predictions from data-driven network models

The paper develops a computational model of SNr neurons to study how dopamine depletion affects firing patterns and identifies TRPC3 conductance reduction as a key factor.

Stimulation of the Medial SNr Promotes Sustained Motor Recovery and Counteracts Parkinsonian Pathophysiology in Dopamine Depleted Mice

This study shows that stimulating specific neurons in the SNr of dopamine-depleted mice leads to sustained motor recovery and reduced parkinsonian symptoms, while global SNr inhibition only provides temporary effects.

A disynaptic circuit in the globus pallidus controls locomotion inhibition

This study identifies a disynaptic circuit in the globus pallidus involving arkypallidal neurons that inhibits locomotion.

Opto-activation of cortical somatostatin interneurons alleviates parkinsonian symptoms

The paper shows opto-activation of cortical somatostatin interneurons alleviates motor symptoms in a Parkinson's mouse model.