Aryn H. Gittis

Altered SNr activity under dopamine depletion: mechanistic predictions from data-driven network models

The paper develops a computational model of SNr neurons to study how dopamine depletion affects firing patterns and identifies TRPC3 conductance reduction as a key factor.

Dissociable roles of central striatum and anterior lateral motor area in initiating and sustaining naturalistic behavior

This study investigates the roles of central striatum (CS) and anterior lateral motor area (ALM) in initiating and sustaining naturalistic grooming behavior using fiber photometry and optogenetic stimulation in mice.

Stimulation of the Medial SNr Promotes Sustained Motor Recovery and Counteracts Parkinsonian Pathophysiology in Dopamine Depleted Mice

This study shows that stimulating specific neurons in the SNr of dopamine-depleted mice leads to sustained motor recovery and reduced parkinsonian symptoms, while global SNr inhibition only provides temporary effects.

The Indirect Pathway of the Basal Ganglia Promotes Negative Reinforcement, But Not Motor Suppression

This study shows that optogenetic stimulation of A2A-SPNs in the striatum drives negative reinforcement via the indirect pathway, not motor suppression.

A computational model explains and predicts substantia nigra pars reticulata responses to pallidal and striatal inputs

This study combines experimental and computational approaches to explain and predict SNr responses to striatal and GPe inputs, revealing chloride dynamics and GPe's role in modulating SNr activity.

Delta oscillations are a robust biomarker of dopamine depletion severity and motor dysfunction in awake mice

The paper identifies delta oscillations as a reliable biomarker for dopamine depletion and motor dysfunction in awake mice, outperforming traditional measures.