Author

John E. Parker

University of PittsburghORCID 0000-0002-1407-4356Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Assay:electronic health records· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Approach:statistical model· 1

Frequent Co-Authors

Aryn H. GittisiD· 2 shared Asier AristietaiD· 2 shared Jonathan E. RubiniD· 2 shared Byung Kook LimiD· 1 shared Mary D. CundiffiD· 1 shared Thomas Fuchs· 1 shared Ya Emma Gao· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

7 top collaborators · 18 mutual co-author links

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2 shared papersNeuroscience

Aryn H. GittisORCID

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2 papers

Recent·Most cited

Altered SNr activity under dopamine depletion: mechanistic predictions from data-driven network models

John E. Parker, Asier Aristieta, Ya Emma Gao, Aryn H. Gittis, Jonathan E. Rubin

The paper develops a computational model of SNr neurons to study how dopamine depletion affects firing patterns and identifies TRPC3 conductance reduction as a key factor.

bioRxiv · Aug 15, 2025 · PreprintNeuroscience

Stimulation of the Medial SNr Promotes Sustained Motor Recovery and Counteracts Parkinsonian Pathophysiology in Dopamine Depleted Mice

Asier Aristieta, John E. Parker, Mary D. Cundiff, Thomas Fuchs, Byung Kook Lim, Jonathan E. Rubin, Aryn H. Gittis

This study shows that stimulating specific neurons in the SNr of dopamine-depleted mice leads to sustained motor recovery and reduced parkinsonian symptoms, while global SNr inhibition only provides temporary effects.

bioRxiv · Dec 9, 2024 · PreprintNeuroscience