Author

Thomas Hofmeister

Thermo Fisher Scientific (Germany)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Approach:benchmark study· 1 Assay:DNA methylation· 1 Organism:human· 1 Approach:statistical model· 1 Research Focus:variant effect prediction· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Chava Kimchi‐SarfatyiD· 1 shared Christine MordsteiniD· 1 shared Eleanor R. GauntiD· 1 shared Fernando Bellido MolíasiD· 1 shared Grzegorz R. KudlaiD· 1 shared Laura Cano-Aroca· 1 shared Laurence D. HurstiD· 1 shared Marguerite J. Clarke· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperSynthetic Biology

Chava Kimchi‐SarfatyORCID

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1 paper

Recent·Most cited

Splice-Aware Optimization Prevents Pervasive Missplicing of Natural and Synthetic cDNAs

Mohd Ahmad, Fernando Bellido Molías, Laura Cano-Aroca, Christine Mordstein, Samir F. Watson, Nabid Bhuiyan, Marguerite J. Clarke, Chava Kimchi‐Sarfaty, Upendra Katneni, Eleanor R. Gaunt, Laurence D. Hurst, Nikolai Netuschil, Thomas Hofmeister, Michael A. Liss, Grzegorz R. Kudla

The paper identifies missplicing as a common issue in heterologous gene expression and develops a splice-aware optimization algorithm to improve transgene performance.

bioRxiv · May 25, 2026 · PreprintSynthetic Biology