Author

Christine Mordstein

Institute of Genetics and CancerORCID 0000-0003-4003-2819Unclaimed ORCID profile · follow to get notified of new preprints

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Synthetic Biology· 2

Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:statistical model· 2 Approach:benchmark study· 1 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Grzegorz R. KudlaiD· 2 shared Laurence D. HurstiD· 2 shared Michael Andre LissiD· 2 shared Chava Kimchi‐SarfatyiD· 1 shared Eleanor R. GauntiD· 1 shared Fernando Bellido MolíasiD· 1 shared Jeanne BazileiD· 1 shared Juliet LuftiD· 1 shared

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2019-2026 · peak 1/yr

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10 top collaborators · 33 mutual co-author links

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2 shared papersSynthetic Biology

Grzegorz R. KudlaORCID

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2 papers

Recent·Most cited

Synthetic BiologybioRxivPreprintMay 25, 2026

Splice-Aware Optimization Prevents Pervasive Missplicing of Natural and Synthetic cDNAs

Mohd Ahmad, Fernando Bellido Molías, Laura Cano-Aroca…·Grzegorz R. Kudla

The paper identifies missplicing as a common issue in heterologous gene expression and develops a splice-aware optimization algorithm to improve transgene performance.

1 citation

humanDNA methylation

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Synthetic BiologybioRxivPreprintJan 22, 2019

Splicing buffers suboptimal codon usage in human cells

Christine Mordstein, Rosina Savisaar, Robert S Young…·Grzegorz R. Kudla

The paper shows splicing enhances expression of AT-rich genes by increasing mRNA stability and cytoplasmic localization, while GC-rich genes are less affected by splicing.

DOI 10.1101/527440

humanbulk RNA-seq

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