Author

Chava Kimchi‐Sarfaty

Center for Biologics Evaluation and ResearchORCID 0000-0002-9355-8585Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 2 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Organism:human· 2 Research Focus:variant effect prediction· 2 Assay:whole-genome sequencing· 2 Approach:benchmark study· 1 Assay:DNA methylation· 1 Organism:virus· 1

Frequent Co-Authors

Aikaterini AlexakiiD· 2 shared Anton A. KomariD· 2 shared David D. HolcombiD· 2 shared Jacob M. KamesiD· 2 shared Michael N. DiCuccioiD· 2 shared Nobuko Hamasaki‐KatagiriiD· 2 shared Christine MordsteiniD· 1 shared Eleanor R. GauntiD· 1 shared

Activity by Year

2020-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersBioinformatics

Aikaterini AlexakiORCID

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Author profile →

3 papers

Recent·Most cited

Splice-Aware Optimization Prevents Pervasive Missplicing of Natural and Synthetic cDNAs

Mohd Ahmad, Fernando Bellido Molías, Laura Cano-Aroca, Christine Mordstein, Samir F. Watson, Nabid Bhuiyan, Marguerite J. Clarke, Chava Kimchi‐Sarfaty, Upendra Katneni, Eleanor R. Gaunt, Laurence D. Hurst, Nikolai Netuschil, Thomas Hofmeister, Michael A. Liss, Grzegorz R. Kudla

The paper identifies missplicing as a common issue in heterologous gene expression and develops a splice-aware optimization algorithm to improve transgene performance.

bioRxiv · May 25, 2026 · PreprintSynthetic Biology

Sequence analysis of SARS-CoV-2 genome reveals features important for vaccine design

Jacob M. Kames, David D. Holcomb, Ofer Kimchi, Michael N. DiCuccio, Nobuko Hamasaki‐Katagiri, Tony T. Wang, Anton A. Komar, Aikaterini Alexaki, Chava Kimchi‐Sarfaty

The paper analyzes SARS-CoV-2 genomic features to identify targets for vaccine development through codon pair deoptimization.

Scientific Reports · Sep 24, 2020Peer-reviewedBioinformatics

Potential impact on coagulopathy of gene variants of coagulation related proteins that interact with SARS-CoV-2

David D. Holcomb, Aikaterini Alexaki, Nancy E. Hernandez, Kyle Laurie, Jacob M. Kames, Nobuko Hamasaki‐Katagiri, Anton A. Komar, Michael N. DiCuccio, Chava Kimchi‐Sarfaty

The paper examines how genetic variants of coagulation-related proteins interacting with SARS-CoV-2 may influence COVID-19 severity, particularly in minority populations.

bioRxiv · Sep 8, 2020 · PreprintBioinformatics