Cyclin-dependent-like kinase 5 is required for pain signalling in both human neurons and mouse models
Paolo La Montanara, Arnau Hervera, Lucas L. Baltussen, Thomas Hutson, Ilaria Palmisano, Francesco De Virgiliis, Yunan Gao, Qasim A. Majid, Nikos Gorgoraptis, Kingsley Wong, Jenny Anne Downs, Vincenzo Di Lazzaro, Tommaso Pizzorusso, Sila K. Ultanir, Helen Leonard, , Simone Di Giovanni
This study identifies Cdkl5's role in pain signaling through its interaction with CaMKII in both human neurons and mouse models of Cdkl5 deficiency disorder.
bioRxiv · Jul 2, 2019 · PreprintNeuroscience