Francesco De Virgiliis

Three-dimensional chromatin mapping of sensory neurons reveals that cohesin-dependent genomic domains are required for axonal regeneration

This study maps the 3D chromatin architecture of adult sensory neurons and shows cohesin is required for axonal regeneration by organizing genomic domains.

The circadian clock is a pacemaker of the axonal regenerative ability

This study identifies circadian rhythms as a key regulator of axonal regenerative ability in DRG neurons, showing that clock genes like Bmal1 are essential for regeneration and that chrono-active drugs like lithium can enhance nerve repair.

Combinatorial small molecule-mediated activation of CBP/p300 with environmental enrichment in chronic severe experimental spinal cord injury to enable axon regeneration and sprouting for functional recovery

Cyclin-dependent-like kinase 5 is required for pain signalling in both human neurons and mouse models

This study identifies Cdkl5's role in pain signaling through its interaction with CaMKII in both human neurons and mouse models of Cdkl5 deficiency disorder.

Combinatorial proteomics and transcriptomics identify AMPK in the control of the axonal regeneration programme of DRG sensory neurons after spinal injury

PP4-dependent HDAC3 dephosphorylation discriminates between axonal regeneration and regenerative failure

The paper identifies PP4-dependent HDAC3 dephosphorylation as a mechanism distinguishing axonal regeneration from regenerative failure in nerve injuries.