Tommaso Pizzorusso

This study shows that CDKL5 deficiency in mice leads to sensory processing defects in the barrel cortex and autistic traits, which can be rescued by neonatal CDKL5 replacement.

The paper identifies a distributed brain network involved in episodic-like memory retrieval in mice by analyzing c-Fos activation and chemogenetic manipulations.

This study shows that miR-29 regulates memory stability, synaptic gene expression, and DNA methylation in adult mouse hippocampus by modulating Dnmt3a levels.

This study investigates gut microbiota changes in CDKL5 deficiency disorder mouse models and shows that antibiotic treatment improves neurological outcomes and microglial function.

This study uses pupillometry and whole-brain c-Fos mapping to show that emotional contagion in mice involves shared neural activation and multisensory processing.

The paper creates a comprehensive atlas of perineuronal net distribution and colocalization with parvalbumin cells in the adult mouse brain, revealing correlations with synaptic plasticity and circuit stability.

This study shows that mGluR5 positive-allosteric modulators correct synaptic and behavioural defects in a CDKL5 deficiency disorder mouse model and human patients.

This study shows that gut microbiota changes in enriched environment mice regulate visual cortical plasticity through short-chain fatty acids.

MEYE is a web app using a Convolutional Neural Network to perform real-time pupillometry in mice and humans, offering a simple and accessible tool for non-specialists.

This study shows that using a secretable TATk-CDKL5 protein in AAV gene therapy improves CDKL5 replacement and functional outcomes in Cdkl5 KO mice compared to native CDKL5 expression.

This study identifies that combined optogenetic stimulation and motor training restores pre-stroke motor-evoked cortical activity, distinguishing it as the most effective post-stroke rehabilitation therapy.

The paper shows that restoring C6S levels in aged brains improves memory by reversing perineuronal net inhibition.

This study identifies Cdkl5's role in pain signaling through its interaction with CaMKII in both human neurons and mouse models of Cdkl5 deficiency disorder.

This study shows that p75NTR regulates PV cell connectivity maturation and promotes adult visual cortex plasticity by controlling synaptic timing and connectivity stability.

This study shows that perineuronal nets (PNNs) in the adult mouse visual cortex regulate thalamic recruitment of PV interneurons, affecting visual processing and plasticity.