Phosphorylated ubiquitin is a secondary messenger and an epigenetic mark mediating mitochondria to nucleus signaling
Thomas J. Mercer, Bence Dániel, Craig Fredrickson, Daniel Le, Serena Lee, Vineet Vinay Kulkarni, Xu Hou, Fabienne C. Fiesel, Hai Ngu, Min Jung, Brent James Ryan, Rachel Heon‐Roberts, Amelia Smith, Vasumathi Kameswaran, Tommy K. Cheung, , Bariş Bingöl
This study identifies phosphorylated ubiquitin (pS65Ub) as a signaling molecule that mediates mitochondrial-to-nuclear communication by modulating histone ubiquitination and gene expression in Parkinson's disease.
bioRxiv · Apr 25, 2026 · PreprintCell Biology