Author

Baris Bingol

GenentechORCID 0000-0002-8225-4367Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Molecular Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Assay:proteomics· 2 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1

Frequent Co-Authors

Hai NguiD· 2 shared Oded ForemaniD· 2 shared Sarah Chu· 2 shared Amelia Smith· 1 shared Amy E. EastoniD· 1 shared Bence DánieliD· 1 shared Brent James RyaniD· 1 shared Christopher M. RoseiD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersNeuroscience

Hai NguORCID

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Author profile →

3 papers

Recent·Most cited

Intranigral injection of Alpha-Synuclein pre-formed fibrils leads to BBB compromise and Bilateral Dopaminergic Neurodegeneration in A53T Alpha-Synuclein transgenic mice.

Soumitra Ghosh, Han Lin, Sarah Chu, Hai Ngu, Nanzhi Zang, Renee Raman, Kimberly L. Stark, Oded Foreman, Somaye Sadat Hashemifar, Amy E. Easton, Baris Bingol, William J. Meilandt

This study develops a mouse model of Parkinson's disease by injecting alpha-synuclein pre-formed fibrils, leading to bilateral dopaminergic neurodegeneration and BBB compromise.

Discover Neuroscience · Aug 27, 2026Peer-reviewedNeuroscience

Phosphorylated ubiquitin is a secondary messenger and an epigenetic mark mediating mitochondria to nucleus signaling

Thomas J. Mercer, Bence Dániel, Craig Fredrickson, Daniel Le, Serena Lee, Vineet Vinay Kulkarni, Xu Hou, Fabienne C. Fiesel, Hai Ngu, Min Jung, Brent James Ryan, Rachel Heon‐Roberts, Amelia Smith, Vasumathi Kameswaran, Tommy K. Cheung, , Bariş Bingöl

This study identifies phosphorylated ubiquitin (pS65Ub) as a signaling molecule that mediates mitochondrial-to-nuclear communication by modulating histone ubiquitination and gene expression in Parkinson's disease.

bioRxiv · Apr 25, 2026 · PreprintCell Biology

Protein degradation by small tag artificial bacterial E3 ligase

Zhenyi Liu, Ming‐Chi Tsai, Soumitra Ghosh, Jessica Lawrence, Sarah Chu, Baris Bingol, Søren Warming

This paper introduces a method to degrade proteins using small tags and an artificial bacterial E3 ligase, demonstrating its effectiveness in neurons and mouse brains.

bioRxiv · Sep 7, 2024 · PreprintMolecular Biology