Tommy K. Cheung

The paper develops nanoMAPS, a droplet-based magnetic affinity purification system for surfaceome profiling of 100-500 cells, improving recovery and reducing non-specific absorption.

The paper determines the cryo-EM structure of the holocentric CCAN from Bombyx mori, revealing a self-contained dimer that forms a point-centromere-like architecture and incorporates novel Centromeric Subunit proteins.

This study identifies phosphorylated ubiquitin (pS65Ub) as a signaling molecule that mediates mitochondrial-to-nuclear communication by modulating histone ubiquitination and gene expression in Parkinson's disease.

The paper introduces toma-scpMS, a method that improves quantification in multiplexed single cell proteomics by separating carrier and single cell proteomes during mass spectrometry.

This paper identifies a potent and specific SMARCA2/A4 degrader, G-6599, which works via FBXO22 recruitment and covalent conjugation, offering therapeutic potential.