Hai Ngu

This study develops a mouse model of Parkinson's disease by injecting alpha-synuclein pre-formed fibrils, leading to bilateral dopaminergic neurodegeneration and BBB compromise.

This study identifies phosphorylated ubiquitin (pS65Ub) as a signaling molecule that mediates mitochondrial-to-nuclear communication by modulating histone ubiquitination and gene expression in Parkinson's disease.

This paper develops a method to quantify immunohistochemistry antigen concentrations and reaction-diffusion parameters, enabling more rigorous interpretation of IHC results.

This study shows that deleting C3aR does not reduce neurodegeneration in a tauopathy model or alter gene expression changes during acute inflammation.

This study shows that TPL2 kinase activity in microglia drives neuroinflammation and neurodegeneration in tauopathy models, suggesting it as a therapeutic target.

The paper identifies a proliferative progenitor-like cell subpopulation in postnatal mouse islets that drives β cell expansion through Notch pathway activity.