Spatiotemporal optical control of Gαq-PLCβ interactions
Sithurandi Ubeysinghe, Dinesh Kankanamge, Waruna Thotamune, Dhanushan Wijayaratna, Thomas M. Mohan, Ajith Karunarathne
This paper introduces an optogenetic tool to control GqGTP-PLCβ interactions and shows its role in regulating cell migration through competition with RhoGEFs.
ACS Synthetic Biology · Dec 13, 2023Peer-reviewedMolecular Biology