Author

Dhanushan Wijayaratna

Boston Children's HospitalORCID 0009-0007-6568-9530Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Organism:human· 1

Frequent Co-Authors

Ajith KarunarathneiD· 2 shared Aleixo M. MuiseiD· 1 shared Danielle WendeliD· 1 shared Dinesh KankanamgeiD· 1 shared Geordie Emberling· 1 shared Hengqi Betty ZhengiD· 1 shared Jay R. ThiagarajahiD· 1 shared Jeffrey LaiD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersCell Biology

Ajith KarunarathneORCID

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3 papers

Recent·Most cited

Cell BiologybioRxivPreprintJan 30, 2026

Novel GαGTP Sensors Reveal Endogenous and Subcellular G Protein Signaling Dynamics

Dhanushan Wijayaratna, Senuri Piyawardana, Ajith Karunarathne

This paper introduces novel GαGTP sensors to measure endogenous G protein signaling dynamics, revealing subtype-dependent dissociation and subcellular regulation.

DOI 10.64898/2026.01.29.702668

experimental assaycell signaling & trafficking

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Cell BiologybioRxivPreprintMar 22, 2025

TTC7A organizes glandular lumen formation in the intestine through a Class II phosphatidylinositol 3-kinase

Katlynn Bugda Gwilt, Dhanushan Wijayaratna, Geordie Emberling…·Jay R. Thiagarajah

This study identifies TTC7A's role in intestinal lumen formation by chaperoning PIK3C2A to generate PI(3,4)P2, with loss-of-function variants causing multiple lumens and rescue possible via exogenous PI(3,4)P2.

DOI 10.1101/2025.03.22.644724

humanexperimental assay

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Molecular BiologyACS Synthetic BiologyPeer-reviewedDec 13, 2023

Spatiotemporal optical control of Gαq-PLCβ interactions

Sithurandi Ubeysinghe, Dinesh Kankanamge, Waruna Thotamune…·Ajith Karunarathne

This paper introduces an optogenetic tool to control GqGTP-PLCβ interactions and shows its role in regulating cell migration through competition with RhoGEFs.

11 citations

experimental assay

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