Plasmodium berghei is resistant to aryl amino acetamides that inhibit P. falciparum growth by targeting the phospholipid transfer protein PfSTART1.
Claudia BG Barnes, Mrittika Chowdury, Dawson B. Ling, Thomas McClean, Alysha H. Literski, Natalie A. Counihan, Oliver Looker, Thorey K. Jonsdottir, Coralie Boulet, William Nguyen, Madeline G. Dans, Emma Y. Mao, Alan F. Cowman, Niall D. Geoghegan, Kelly L. Rogers, , Paul R. Gilson
This paper identifies MMV006833 as an inhibitor of PfSTART1 in P. falciparum but shows it is ineffective against P. berghei due to structural differences and other factors.
bioRxiv · Sep 26, 2026 · PreprintMicrobiology