Author

Natalie A. Counihan

Deakin UniversityORCID 0000-0002-8973-3344Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:plant (other)· 3 Research Focus:drug response / drug discovery· 2 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1

Frequent Co-Authors

Tania F. de Koning‐WardiD· 3 shared Brad E. SleebsiD· 2 shared Brendan S. CrabbiD· 2 shared Coralie BouletiD· 2 shared Madeline G. DansiD· 2 shared Paul R. GilsoniD· 2 shared William NguyeniD· 2 shared Alan F. CowmaniD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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3 shared papersMicrobiology

Tania F. de Koning‐WardORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Plasmodium berghei is resistant to aryl amino acetamides that inhibit P. falciparum growth by targeting the phospholipid transfer protein PfSTART1.

Claudia BG Barnes, Mrittika Chowdury, Dawson B. Ling, Thomas McClean, Alysha H. Literski, Natalie A. Counihan, Oliver Looker, Thorey K. Jonsdottir, Coralie Boulet, William Nguyen, Madeline G. Dans, Emma Y. Mao, Alan F. Cowman, Niall D. Geoghegan, Kelly L. Rogers, , Paul R. Gilson

This paper identifies MMV006833 as an inhibitor of PfSTART1 in P. falciparum but shows it is ineffective against P. berghei due to structural differences and other factors.

bioRxiv · Sep 26, 2026 · PreprintMicrobiology

PfK13-associated artemisinin resistance slows drug activation and enhances antioxidant defence, which can be overcome with sulforaphane.

Ghizal Siddiqui, Carlo Giannangelo, Natalie A. Counihan, Yudong Zhou, Annie Roys, Amanda De Paoli, Bethany M. Anderson, Matthew P. Challis, Lee Ming Yeoh, Stuart A. Ralph, Laura E. Edgington‐Mitchell, Tania F. de Koning‐Ward, Darren J. Creek

This study identifies PfK13 mutations as drivers of artemisinin resistance by enhancing antioxidant defenses, which can be counteracted by sulforaphane.

bioRxiv · Oct 5, 2025 · PreprintMicrobiology

Aryl N-acetamide compounds exert antimalarial activity by acting as agonists of rhomboid protease PfROM8 and cation channel PfCSC1.

Coralie Boulet, Joyanta K. Modak, Natalie A. Counihan, Molly Parkyn Schneider, William Nguyen, Madeline G. Dans, Claudia B. G. Barnes, Zahra Razook, Kirsty McCann, Alyssa E. Barry, Brendan S. Crabb, Brad E. Sleebs, Tania F. de Koning‐Ward, Paul R. Gilson

This study identifies M-512 as an agonist of PfROM8 and PfCSC1, which are essential for Plasmodium falciparum growth, and shows that their dysregulation reduces parasite viability.

bioRxiv · Mar 18, 2025 · PreprintMicrobiology