SMAD4 target genes are part of a transcriptional network that integrates the response to BMP and SHH signaling during early limb bud patterning
Julie Gamart, Iros Barozzi, Frédéric Laurent, Robert Reinhardt, Laurène Ramos Martins, Thomas Oberholzer, Axel Visel, Rolf Zeller, Aimée Zúñiga
The paper identifies SMAD4 target genes and their role in integrating BMP and SHH signaling during early limb bud development, revealing opposing regulatory effects on anterior and posterior gene expression.
Development · Nov 25, 2021Peer-reviewedDevelopmental Biology