Functional architecture of cardiac TF regulatory landscapes in control of mammalian heart development
Virginia Roland, Johannes Tuechler, A. ESPOSITO, Mattia Conte, Matteo Zoia, Ekapaksi Wisnumurti, Virginie Tissières, Julie Gamart, Raquel Rouco, Ines Joao Marques, Akshay Akshay, Vincent Rapp, Brandon J. Mannion, Jennifer A. Akiyama, Prateek Arora, , Marco Osterwalder
The paper identifies essential cardiac enhancer modules and regulatory mechanisms governing heart development, revealing resilience in cis-regulatory architectures and the role of Hand2 upstream regulatory intervals.
bioRxiv · Dec 22, 2025 · PreprintDevelopmental Biology