Robert Reinhardt

This paper introduces a dual-photoreactive adapter to enable rapid, one-step DNA barcoding of antibody panels for multiplexed imaging.

ProPER enables multiplexed molecular-state analysis by converting spatial proximity into DNA readouts, revealing kinetic details of gene induction and splicing.

This study identifies a specific leukemic stem cell (LSC) subtype that drives niche remodeling in AML by altering fibroblast states and suppressing osteolineage differentiation.

This study shows that Eomes regulates UBC differentiation and migration in mice, mirroring human UBC development, and highlights conserved molecular mechanisms in cerebellar development.

This paper introduces a framework for high-plex spectral imaging using DNA-barcoded labeling and programmable signal amplification to improve panel design and unmixing accuracy.

This study identifies Nup153 as a docking point for splicing machinery at the nuclear pore, showing its role in mRNA processing and gene splicing.

This paper develops a multimodal approach combining X-ray computed tomography and light-sheet fluorescence microscopy to visualize gene expression in 3D tissue context, applicable to in vitro models and model organisms.

The paper identifies SMAD4 target genes and their role in integrating BMP and SHH signaling during early limb bud development, revealing opposing regulatory effects on anterior and posterior gene expression.