Rolf Zeller

WNT signaling coordinately controls mouse limb bud outgrowth and establishment of the digit-interdigit pattern

This study identifies early transcriptional targets of WNT signaling during limb bud and digit development by transiently blocking WNT signaling with small molecule inhibitors.

Single-cell profiling of penta- and tetradactyl mouse limb buds identifies mesenchymal progenitors controlling digit numbers and identities

This study identifies mesenchymal progenitors in mouse limb buds that regulate digit numbers and identities through BMP signaling and GREM1-mediated antagonism.

TBX3 is essential to establish the posterior boundary of anterior genes and up-regulate posterior genes with HAND2 during onset of limb bud development

The paper identifies TBX3 as a key transcription factor for establishing the antero-posterior axis polarity in mouse limb buds by repressing anterior genes and up-regulating posterior genes with HAND2.

A spatio-temporally constrained gene regulatory network directed by PBX1/2 acquires limb patterning specificity via HAND2

The paper reconstructs a gene regulatory network directed by PBX1/2 and HAND2 in mouse limb development, showing their genetic interaction and tissue-specific function.

SMAD4 target genes are part of a transcriptional network that integrates the response to BMP and SHH signaling during early limb bud patterning

The paper identifies SMAD4 target genes and their role in integrating BMP and SHH signaling during early limb bud development, revealing opposing regulatory effects on anterior and posterior gene expression.

Gli3 utilizes Hand2 to synergistically regulate tissue-specific transcriptional networks

This study shows Gli3 and Hand2 work together to control gene expression in craniofacial development without relying on a graded Hh signal.

HOX13-dependent chromatin accessibility modulates the target repertoires of the HOX factors

The paper shows HOX13 factors modulate HOXA11 target repertoire through chromatin accessibility, revealing a mechanism for HOX binding specificity.