Ddx3x regulates B-cell development and immunoglobulin rearrangement in mice
Ke Liu, Durga Krishnamurthy, Jasmine A. Tuazon, Eshana Mukhopadhyay, Harsha Seelamneni, Erik P. Karmele, Omer A. Donmez, Thomas Perlot, Michelle Foong-Sobis, Rebekah A. Karns, Malay Mandal, Damien Reynaud, Leah Claire Kottyan, Matthew T. Weirauch, Wen-Hai Shao, , Stephen N. Waggoner
This study shows that Ddx3x is essential for B-cell development in mice, with loss leading to developmental blocks and defects in immunoglobulin rearrangement.
bioRxiv · Nov 28, 2025 · PreprintImmunology