Author

Erik P. Karmele

Cincinnati Children's Hospital Medical CenterORCID 0000-0002-0695-7343Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1 Approach:experimental assay· 1 Organism:mouse· 1

Frequent Co-Authors

Damien ReynaudiD· 1 shared Durga KrishnamurthyiD· 1 shared Eshana MukhopadhyayiD· 1 shared Harsha Seelamneni· 1 shared Jasmine A. TuazoniD· 1 shared John B. HarleyiD· 1 shared Josef Martin PenningeriD· 1 shared Ke LiuiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperImmunology

Damien ReynaudORCID

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1 paper

Recent·Most cited

Ddx3x regulates B-cell development and immunoglobulin rearrangement in mice

Ke Liu, Durga Krishnamurthy, Jasmine A. Tuazon, Eshana Mukhopadhyay, Harsha Seelamneni, Erik P. Karmele, Omer A. Donmez, Thomas Perlot, Michelle Foong-Sobis, Rebekah A. Karns, Malay Mandal, Damien Reynaud, Leah Claire Kottyan, Matthew T. Weirauch, Wen-Hai Shao, , Stephen N. Waggoner

This study shows that Ddx3x is essential for B-cell development in mice, with loss leading to developmental blocks and defects in immunoglobulin rearrangement.

bioRxiv · Nov 28, 2025 · PreprintImmunology