Author

Thora K. McIssac

Cornell University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

Clea S. CraneiD· 1 shared Richard A. CerioneiD· 1 shared Scott Michael UlrichiD· 1 shared Shawn K. MilanoiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

4 top collaborators · 6 mutual co-author links

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1 shared paperBiochemistry

Clea S. CraneORCID

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1 paper

Recent·Most cited

Structure and enzymology of glutaminase mutants that disrupt glutamine-glutamate homeostasis and cause neurological disease

Clea S. Crane, Thora K. McIssac, Shawn K. Milano, Richard A. Cerione, Scott Michael Ulrich

This study examines two GLS mutants causing neurological disease, finding they lose glutamate inhibition and phosphate dependency, leading to glutamate accumulation and disrupted homeostasis.

Journal of Biological Chemistry · Apr 27, 2026Peer-reviewedBiochemistry