Author

Shawn K. Milano

Cornell UniversityORCID 0000-0003-3624-0113Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Research Focus:protein folding & dynamics· 2 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Assay:protein structure· 1 Assay:proteomics· 1 Assay:structural biology· 1

Frequent Co-Authors

Richard A. CerioneiD· 3 shared Clea S. CraneiD· 1 shared Cody ApliniD· 1 shared Deborah Ogunribido· 1 shared Kara A. ZielinskiiD· 1 shared Lois PollackiD· 1 shared Matt Stankus· 1 shared Megan XuiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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3 shared papersBiochemistry

Richard A. CerioneORCID

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3 papers

Recent·Most cited

BiochemistryJournal of Biological ChemistryPeer-reviewedApr 27, 2026

Structure and enzymology of glutaminase mutants that disrupt glutamine-glutamate homeostasis and cause neurological disease

Clea S. Crane, Thora K. McIssac, Shawn K. Milano…·Scott Michael Ulrich

This study examines two GLS mutants causing neurological disease, finding they lose glutamate inhibition and phosphate dependency, leading to glutamate accumulation and disrupted homeostasis.

DOI 10.1016/j.jbc.2026.113091

humanproteomics

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BiochemistrybioRxivPreprintFeb 27, 2025

Revealing Functional Hotspots: Temperature-Dependent Crystallography of K-RAS Highlights Allosteric and Druggable Sites

Samuel L. Deck, Megan Xu, Matt Stankus…·Richard A. Cerione

This study uses multi-temperature X-ray crystallography to reveal temperature-dependent conformational changes in K-RAS, identifying new druggable sites and highlighting the limitations of cryogenic conditions in capturing dynamic states.

DOI 10.1101/2025.02.27.639303

humanprotein structure

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BiophysicsCommunications BiologyPeer-reviewedAug 13, 2024

Defining the conformational states that enable transglutaminase 2 to promote cancer cell survival versus cell death

Cody Aplin, Kara A. Zielinski, Suzette A. Pabit…·Shawn K. Milano

This paper investigates the conformational states of TG2 and shows how an inhibitor stabilizes an open conformation that is cytotoxic to cancer cells.

15 citations

structural biologyexperimental assay

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