LAMP2A-dependent chaperone-mediated autophagy enhances oxidative stress resistance in gastric cancer cells through selective degradation of accumulated oxidized DJ-1
Shuangshuang Le, Tongtong Guo, Meng Yang, Tianjuan Tang, Zhijie Liu, Zheng Yang, Maogui Pang
This study shows that LAMP2A-dependent CMA enhances oxidative stress resistance in gastric cancer by degrading oxidized DJ-1, preventing apoptosis and promoting survival.
PLoS ONE · May 15, 2026Peer-reviewedCancer Biology