Distinct HPO axis responses and ovarian aging trajectories to chronic unpredictable mild stress in reproductively young versus middle-aged female mice
Tiannuo Yang, Shuqin Zhang, Danqi Liu, Laijia Li, Kunpeng Zhou, Yufeng Han, Jianchuan Wang, Hanwen Zhang, Yiqing Ma, Shangxuan Liu, Boyu Ma, Furui Jin, Jian Li, Ying Wang, Zelan Hu
This study shows that chronic unpredictable mild stress induces age-dependent ovarian aging and POI in young and middle-aged female mice, with distinct endocrine and transcriptomic responses.
bioRxiv · Apr 28, 2026 · PreprintPhysiology