PhysiologybioRxivPreprint
Distinct HPO axis responses and ovarian aging trajectories to chronic unpredictable mild stress in reproductively young versus middle-aged female mice
Tiannuo Yang, Shuqin Zhang, Danqi Liu…·Zelan Hu
This study shows that chronic unpredictable mild stress induces age-dependent ovarian aging and POI in young and middle-aged female mice, with distinct endocrine and transcriptomic responses.
DOI 10.64898/2026.04.24.720585