METTL14-dependent m6A modification restrains interferon signaling to prevent myocarditis and dilated Cardiomyopathy
Yu Xi, Jacob Kuempel, Sukwon Choi, Patrick S DeSpain, Tianru Zhang, Jiaying Zhu, Abi Osborn, Reed A Rivera, Songxiao Zhong, Xiaoyang Wu, Yong-Xiao Wang, Zhenyu Li, Andrew Phillip West, Changhao Li, Carl Wei-Chan Tong, , Xu Peng
This study shows that METTL14-dependent m6A modification prevents myocarditis and dilated cardiomyopathy by restraining IFN signaling and necroptosis in cardiomyocytes.
bioRxiv · Apr 6, 2026 · PreprintPathology