Songxiao Zhong

This study shows that METTL14-dependent m6A modification prevents myocarditis and dilated cardiomyopathy by restraining IFN signaling and necroptosis in cardiomyocytes.

The paper identifies U1-70k as a novel spliceosome factor that facilitates RNA silencing by co-condensing with SGS3 to load nascent transcripts into the PTGS pathway.