Study on gene knockout mice and human mutant individual reveals absence of CEP78 causes photoreceptor and sperm flagella impairments
Tianyu Zhu, Yuxin Zhang, Xunlun Sheng, Xiangzheng Zhang, Yu Chen, Hong-Jing Zhu, Yueshuai Guo, Yaling Qi, Yichen Zhao, Qi Zhou, Xue Chen, Xuejiang Guo, Chen Zhao
This study identifies CEP78 as a causative gene for cone-rod dystrophy and male infertility, showing its role in photoreceptor and sperm flagella development through mouse models and human patient analysis.
eLife · Feb 9, 2023Peer-reviewedDevelopmental Biology