circASbase is a database cataloging 452,129 alternative splicing events in 884,047 circRNAs from 581 samples across 13 species, revealing unique splicing features and functional impacts of circRNAs.

Genomics Proteomics & Bioinformatics · Dec 2, 2025Peer-reviewedBioinformatics

Separately prestored proteasome components to prevent polyspermy

Liying Wang, Chao Liu, Xing Wang, Yueshuai Guo, Qiuxing Zhou, Yinghong Chen, Huafang Wei, Xiaoming Huang, Shuai Liu, Wei Li, Chun So, Ling Sun, Renjie Jiao, Xuejiang Guo, Qiang Guo

The paper shows that testis-specific 20S proteasome core particles in sperm help prevent polyspermy by forming chimeric proteasomes that degrade Fetuin B, leading to zona pellucida hardening.

bioRxiv · Sep 1, 2025 · PreprintDevelopmental Biology

Study on gene knockout mice and human mutant individual reveals absence of CEP78 causes photoreceptor and sperm flagella impairments

Tianyu Zhu, Yuxin Zhang, Xunlun Sheng, Xiangzheng Zhang, Yu Chen, Hong-Jing Zhu, Yueshuai Guo, Yaling Qi, Yichen Zhao, Qi Zhou, Xue Chen, Xuejiang Guo, Chen Zhao

This study identifies CEP78 as a causative gene for cone-rod dystrophy and male infertility, showing its role in photoreceptor and sperm flagella development through mouse models and human patient analysis.

eLife · Feb 9, 2023Peer-reviewedDevelopmental Biology

IRESbase: a Comprehensive Database of Experimentally Validated Internal Ribosome Entry Sites

Jian Zhao, Yan Li, Cong Wang, Haotian Zhang, Hao Zhang, Bin Jiang, Xuejiang Guo, Xiaofeng Song

IRESbase is a database of experimentally validated IRES elements, containing 1328 IRESs from 11 eukaryotic organisms and 198 viruses, mapped to circRNAs and lncRNAs.

Genomics Proteomics & Bioinformatics · Apr 1, 2020Peer-reviewedBioinformatics