Author

Yu Chen

Wenzhou Medical UniversityORCID 0000-0002-9910-6942Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Yu Chen14 papers · Bristol-Myers Squibb (United States)

Biology Disciplines

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Developmental Biology· 1 Genetics· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

Ling HouiD· 2 shared Xiaoyin MaiD· 2 shared Bo Liu· 1 shared Chen ZhaoiD· 1 shared Hang Yu· 1 shared Hong-Jing Zhu· 1 shared Huirong LiiD· 1 shared Jia QuiD· 1 shared

Activity by Year

2020-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersGenetics

Ling HouORCID

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3 papers

Recent·Most cited

Retinal pigment epithelium-derived PD-L1 reprograms microglial cells and protects against retinal degeneration in mouse models of experimental AMD and genetic retinitis pigmentosa

Zhongyuan Su, Jing Wang, Qinghua Lai, Zhenhang Wang, Pingping Liu, Zhiyan Tang, Hang Yu, Yu Chen, Xiaoyin Ma, Ling Hou

This study shows that PD-L1 from retinal pigment epithelium reprograms microglia to reduce inflammation and protect against retinal degeneration in mouse models.

bioRxiv · Jul 26, 2025 · PreprintGenetics

Study on gene knockout mice and human mutant individual reveals absence of CEP78 causes photoreceptor and sperm flagella impairments

Tianyu Zhu, Yuxin Zhang, Xunlun Sheng, Xiangzheng Zhang, Yu Chen, Hong-Jing Zhu, Yueshuai Guo, Yaling Qi, Yichen Zhao, Qi Zhou, Xue Chen, Xuejiang Guo, Chen Zhao

This study identifies CEP78 as a causative gene for cone-rod dystrophy and male infertility, showing its role in photoreceptor and sperm flagella development through mouse models and human patient analysis.

eLife · Feb 9, 2023Peer-reviewedDevelopmental Biology

KIT ligand protects against both light-induced and genetic photoreceptor degeneration

Huirong Li, Lili Lian, Bo Liu, Yu Chen, Jinglei Yang, Shuhui Jian, Jiajia Zhou, Ying Xu, Xiaoyin Ma, Jia Qu, Ling Hou

The paper shows that KIT ligand protects photoreceptor cells from light-induced and genetic degeneration by activating NRF2 and Hmox1.

eLife · Apr 3, 2020Peer-reviewedNeuroscience