Developmental BiologybioRxivPreprint
Separately prestored proteasome components to prevent polyspermy
Liying Wang, Chao Liu, Xing Wang…·Qiang Guo
The paper shows that testis-specific 20S proteasome core particles in sperm help prevent polyspermy by forming chimeric proteasomes that degrade Fetuin B, leading to zona pellucida hardening.