A Tiered Approach to Human Synapse Proteomics: Optimized LC-MS/MS Analysis of Whole-Tissue and Synaptosome Preparations from Frozen Post-Mortem Brain Samples
Femke Roig Kuhn, Remco V. Klaassen, Frank Koopmans, Tiara S.Z. Koolman, August B. SMIT, Sabine Spijker
The paper compares whole-tissue and synaptosome proteomics using LC-MS/MS to evaluate synaptic protein detection, recommending a tiered approach for studying brain disorders.
Cells · Apr 21, 2026Peer-reviewedNeuroscience