Exercise induces Skeletal Muscle Methylome and Transcriptome changes, regardless of Age and COPD
Poojitha Rajasekar, Lorna E. Latimer, Linzy Houchen‐Wolloff, Kamini Rakkar, Tim Constantin-Teodosiu, Julie L. MacIsaac, Lisa M. McEwen, Chen Xi Yang, Tillie‐Louise Hackett, Bhavesh Popat, Despina Constantin, Michael Steffen Kobor, MICHAEL C. STEINER, Paul Leonard Greenhaff, Charlotte E. Bolton, Rachel L. Clifford
This study shows exercise induces methylome and transcriptome changes in skeletal muscle, independent of COPD and age, with some changes linked to inflammation and others to tissue remodeling.
bioRxiv · Mar 9, 2026 · PreprintGenomics