Rachel L. Clifford

This study shows that loss of PKN2 leads to fibroblast reprogramming and ECM remodelling in pulmonary fibrosis by altering key pathways and secretion.

This study shows exercise induces methylome and transcriptome changes in skeletal muscle, independent of COPD and age, with some changes linked to inflammation and others to tissue remodeling.

The paper uses spatial multiomic profiling to identify distinct fibrotic epithelial niches in IPF, revealing a KRT5low/KRT17 epithelial population and its association with SPP1 macrophages.