Chen Xi Yang

This study shows exercise induces methylome and transcriptome changes in skeletal muscle, independent of COPD and age, with some changes linked to inflammation and others to tissue remodeling.

The paper develops a rapid, minimal-handling protocol for preparing single-cell suspensions from bronchial brush specimens for scRNA-seq to improve airway disease research.

SMART deconvolves spatial transcriptomics data without a reference, inferring cell type profiles and composition using marker genes, and outperforms existing methods when references are unavailable.

The paper uses multi-omics approaches to identify genes and plasma proteins associated with COVID-19, finding ABO plasma protein as a causal risk factor.

The paper identifies proteins associated with lung function and COPD risk using integrative omics and Mendelian Randomization, finding 37 proteins with causal associations.

The paper identifies co-expressed genes with ACE2 and TMPRSS2 in lung tissue and finds many have drug interactions, suggesting potential targets for COVID-19 therapeutics.

The paper identifies sex-specific transcriptomic responses to smoking in human airway epithelium, revealing sexually dimorphic gene modules associated with autophagy and immune response pathways.