An RNA editing/binding-independent gene regulatory mechanism of ADARs and its clinical implication in cancer
Lihua Qi, Yangyang Song, Tim Hon Man Chan, Henry Yang, Chi Ho Lin, Daryl Jin Tai Tay, HuiQi Hong, Jaymie Siqi Lin, Vanessa Hui En Ng, Julien Jean Pierre Maury, Daniel G Tenen, Leilei (Polly) Chen
This study reveals a non-editing gene regulatory role of ADARs in cancer by enhancing miR-27a processing, which represses METTL7A expression, highlighting a new therapeutic target.
Nucleic Acids Research · Jul 29, 2017Peer-reviewedCancer Biology