Vanessa Hui En Ng

The paper identifies novel ADAR1 isoforms generated by intron retention that sequester dsRNA to inhibit PKR and promote tumorigenesis in colorectal cancer.

This study identifies mitochondrial dsRNA as a major endogenous dsRNA source in ADAR1 deficiency and proposes a mechanism linking ADAR1 dysfunction to immune activation.

This study benchmarks Nanopore long read RNA sequencing in human cell lines, showing improved isoform resolution compared to short reads.

This study reveals a non-editing gene regulatory role of ADARs in cancer by enhancing miR-27a processing, which represses METTL7A expression, highlighting a new therapeutic target.