Selective inhibition of MR1-restricted T cell activation by a novel MR1-targeting nanobody
Timothy Bates, Corinna A. Kulicke, Sintayehu Kebede Gurmessa, Se-Jin Kim, Sushant Suresh, Jules B. Weinstein, Audrey Hinchliff, John E. Burke, David Michael Lewinsohn, Fikadu Tafesse
This study develops a high-affinity anti-MR1 nanobody that selectively inhibits MR1-restricted T cell activation, providing insights into MR1 function and a tool for immunological research.
bioRxiv · Jun 11, 2025 · PreprintImmunology