Se-Jin Kim

This study shows that IL-23 and TCR stimulation together are needed for lung MAIT cells to produce IL-17A, with distinct transcriptional changes observed.

This study identifies Synaptotagmin 1 and 7 as facilitators of MR1-mediated antigen presentation of Mycobacterium tuberculosis to MAIT cells.

This study shows that mutations in MR1 outside the antigen binding groove differentially affect exogenous antigen presentation by altering B2M association.

This study identifies opposing roles for SNAP23 and SNAP25 in MR1 trafficking and antigen presentation to MAIT cells, showing SNAP23 enhances while SNAP25 suppresses antigen presentation.

This study develops a high-affinity anti-MR1 nanobody that selectively inhibits MR1-restricted T cell activation, providing insights into MR1 function and a tool for immunological research.