Drosophila CaV2 Channels Harboring Human Migraine Mutations Cause Synapse Hyperexcitability That Can Be Suppressed By Inhibition Of A Ca2+ Store Release Pathway
Douglas J Brusich, Ashlyn M. Spring, Thomas D. James, Catherine J. Yeates, Timothy H. Helms, C. Andrew Frank
This study introduces Drosophila models with human migraine mutations in CaV2 channels, showing hyperexcitability that can be suppressed by inhibiting intracellular Ca2+ release.
PLoS Genetics · Aug 6, 2018Peer-reviewedNeuroscience